Patients with schizophrenia are typically deficient in vitamin B-3, also known as niacin. In some cases, patients respond quite well to high doses of the vitamin.

Abram Hoffer, M.D., Ph.D., was the first to recognize the B-3/schizophrenia link.

Dr Hoffer treated the sister of Alan Spreen, MD.  According to Spreen, Dr. Hoffer treated his sister, a schizophrenic who had been written off and permanently institutionalized. Her parents were told she’d never be a useful, productive member of society. After being treated by Dr. Hoffer, she ended up graduating law school and passing the bar.

Vitamin B-3 and Schizophrenia
Slo-Niacin Polygel Controlled-Release Niacin, 500 mg, 100 Tablets